Abstract A desmoplastic reaction in the solid tumor microenvironment (TME), typically characterized by extracellular matrix (ECM) dysregulation and an immune suppressive milieu, is a key factor contributing to tumor aggression, therapeutic resistance, metastasis and inevitably poor patient prognosis. Cancer-associated fibroblasts (CAFs), in particular myofibroblast-like CAFs (myCAFs), are central players in the development of TME desmoplasia in the most common and aggressive solid cancers such as breast, lung, head Part 1 (Regular Abstracts); 2026 Apr 17-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2026;86(7 Suppl):Abstract nr 3513.
Möller et al. (Fri,) studied this question.