Highlights the occurrence of subclinical, smoldering myocarditis following immune checkpoint blockade and supports early monitoring with serial ECGs and troponin I to enable early immunosuppression.
This case demonstrates that subclinical, smoldering myocarditis may occur following immune checkpoint blockade, with evidence of both humoral and cell-mediated immunity responsive to corticosteroid therapy. This experience supports early monitoring for myocarditis with serial electrocardiograms and serum troponin I determinations in large, prospective cohorts of patients receiving combination immune checkpoint blockade as early detection and initiation of immunosuppression may forestall fulminant presentation of this disease and limit myocardial damage.
Norwood et al. (Tue,) studied this question.
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