Does clopidogrel plus aspirin reduce secondary stroke in Chinese patients with cerebral infarction or transient ischemic attack combined with intracranial and extracranial arteriostenosis compared to aspirin alone?
Dual antiplatelet therapy with 50 mg clopidogrel plus aspirin may offer an optimal balance of efficacy and safety for secondary stroke prevention in Chinese patients with ischemic cerebrovascular disease and arteriostenosis.
Accordingly, 50 mg clopidogrel plus aspirin, and 75 mg clopidogrel plus aspirin were all superior to aspirin alone as stroke prevention in patients with cerebral infarction or transient ischemic attack combined with intracranial and extracranial arteriostenosis. The effect of secondary stroke prevention was similar between 50 mg clopidogrel plus aspirin and 75 mg clopidogrel plus aspirin. The therapy of 75 mg clopidogrel plus aspirin resulted in a worrisome tread in bleeding events.
Zuo et al. (Sun,) studied this question.