How do the ACC/AHA, ATP-III, and ESC guidelines compare regarding statin eligibility and risk prediction in a European population aged 55 years or older?
Application of ACC/AHA guidelines in a European cohort aged ≥55 years substantially increases statin eligibility compared to ATP-III and ESC guidelines, though all three risk models show poor calibration.
In this European population aged 55 years or older, proportions of individuals eligible for statins differed substantially among the guidelines. The ACC/AHA guideline would recommend statins for nearly all men and two-thirds of women, proportions exceeding those with the ATP-III or ESC guidelines. All 3 risk models provided poor calibration and moderate to good discrimination. Improving risk predictions and setting appropriate population-wide thresholds are necessary to facilitate better clinical decision making.
Kavousi et al. (Sat,) studied this question.
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