Does Tenascin-C aggravate autoimmune myocarditis via dendritic cell activation and Th17 differentiation?
Blockade of Toll-like receptor 4-mediated signaling may be a promising therapeutic strategy against autoimmune myocarditis by inhibiting the proinflammatory effects of TN-C.
Our results demonstrated that TN-C aggravates autoimmune myocarditis by driving the dendritic cell activation and Th17 differentiation via Toll-like receptor 4. The blockade of Toll-like receptor 4-mediated signaling to inhibit the proinflammatory effects of TN-C could be a promising therapeutic strategy against autoimmune myocarditis.
Machino‐Ohtsuka et al. (Fri,) studied this question.