Blood pressure is the most important modifiable determinant of increasing arterial stiffness over 5 years in patients with early CKD, highlighting the need for strict BP control.
We observed a clinically significant increase in PWV over 5 years in a cohort with early CKD despite reasonably well-controlled hypertension. Measures of BP were identified as the most important modifiable determinant of ΔPWV, suggesting that interventions to prevent arterial disease should focus on improved control of BP, particularly in those who evidence an early increase in PWV. These hypotheses should now be tested in prospective trials.
McIntyre et al. (Wed,) studied this question.