Does dexrazoxane prevent anthracycline cardiotoxicity via TOP2B interaction rather than metal chelation?
Dexrazoxane prevents anthracycline cardiotoxicity through TOP2B interaction rather than metal chelation, shifting the mechanistic paradigm of its cardioprotective effects.
This study strongly supports a new mechanistic paradigm that attributes clinically effective cardioprotection against anthracycline cardiotoxicity to interactions with TOP2B but not metal chelation and protection against direct oxidative damage.
Jirkovský et al. (Thu,) studied this question.