What question did this study set out to answer?

The aim is to explore a novel alcohol mediated synthesis of 2-amino-naphtho[2,3-b]furan-4,9-dione derivatives.

April 8, 2026

Alcohol Mediated Isocyanide Domino Reactions Toward 2-Aminofuronaphthoquinones

Key Points

The aim is to explore a novel alcohol mediated synthesis of 2-amino-naphtho[2,3-b]furan-4,9-dione derivatives.
Utilized 2-hydroxy-1,4-naphthoquinones and isocyanides
Applied microwave irradiation for reaction enhancement
Used Yb(OTf)3 as a catalyst in alcohol media
Successfully synthesized various 2-amino-naphtho[2,3-b]furan-4,9-dione derivatives
Demonstrated the effect of different alcohol media on reaction outcomes
Enhanced reaction efficiency noted under microwave conditions

Abstract

An unprecedented alcohol mediated formation of 2-amino-naphtho2,3-bfuran-4,9-dione derivatives from 2-hydroxy-1,4-naphthoquinones and isocyanides under microwave irradiation in the presence of Yb(OTf)3 is reported. The effect of different alcohol media, isocyanides and...

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