July 1, 1999

Enhanced production of interleukin-6 (IL-6), oncostatin M and soluble IL-6 receptor by cultured peripheral blood mononuclear cells from patients with systemic sclerosis

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Abstract

The enhanced production of IL-6, OSM and sIL-6R from PBMC may cooperatively contribute to the disease process in SSc. In particular, enhanced sIL-6R production from PBMC may be related to the development of pulmonary fibrosis via enhancement of IL-6 signal transduction in SSc, since sIL-6R can act as an agonist of IL-6.

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Minoru Hasegawa (Thu,) studied this question.

synapsesocial.com/papers/69d73490f07a12db70b8a4c8 https://doi.org/https://doi.org/10.1093/rheumatology/38.7.612

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