Renal Tubular Reabsorption of Acetoacetate, Inorganic Sulfate and Inorganic Phosphate in the Dog as Affected by Glucose and Phlorizin

The effects of glucose and phlorizin on the maximal reabsorptive rates of acetoacetate, sulfate and phosphate were studied in the dog. Increased rates of glucose reabsorption depress maximal acetoacetate, sulfate and phosphate transport. Phlorizin not only reverses this depressant effect of glucose on these three ions, but actually raises their maximal reabsorptive rates above those of the control levels. These findings for acetoacetate and sulfate reabsorption are similar to those previously reported for phosphate reabsorption. The three ions, acetoacetate, sulfate and phosphate share a common reaction with glucose during their tubular transport. Glucose is the predominant compound, depressing any of the other three ions after they have reached maximal reabsorptive rates. The possible implications of these phenomena in the general problem of tubular transport are discussed.