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Abstract At present, high-sensitivity, high-penetration-depth, and accurate tissue resolution clinical imaging effect are required, while computer transverse scanning, microwave imaging, and fluorescence imaging (FL) cannot meet the requirements of clinical imaging, but the magnetic resonance imaging (MRI) can meet the requirements of clinical dissecting details. The effect of MRI imaging is closely related to the contrast agent (CA). As an important type of CA, Fe 3 O 4 and its analogues have been widely concerned because of their low toxicity and relatively low price. In this review, we summarize the development and improvement of CAs based on Fe 3 O 4 and its analogues from T 2 imaging mode and development limitation in the initial single modulus imaging mode, to T 1 imaging mode overcoming the limitations of T 2 imaging and the limitations of its own in application, to the later development of dual modulus imaging form, and to the current multi-modulus imaging form. Simultaneously, we demonstrate the research progress, preparation methods, and future trends based on Fe 3 O 4 and its analogues CAs for MRI, the current application status is preliminarily summarized, and the future development trend is prospected.
Li et al. (Wed,) studied this question.