An Efficient Strategy for Quinazolinone and Benzimidazole Synthesis Using Microwave‐Assisted Copper‐Catalyzed Aerobic Oxidation of Amines

Abstract Microwave‐assisted organic synthesis (MAOS) has emerged as an effective technique for accelerating chemical reactions while enhancing efficiency and selectivity. In this study, we developed a copper‐catalyzed method for aerobic oxidative coupling to synthesize quinazolinones and benzimidazoles, using oxone as the oxidant under microwave irradiation. This method successfully couples amines with various partners, including 2‐aminobenzamides and o ‐phenylenediamines. The strategy demonstrates broad substrate compatibility, exhibits good functional group tolerance, and consistently achieves moderate yields, making it a versatile and efficient approach for synthesizing heterocycles.