Understanding genotype-phenotype correlations in LQTS provides insights into arrhythmia mechanisms and highlights the potential for gene-specific therapeutic approaches.
Life-threatening arrhythmias in LQTS patients tend to occur under specific circumstances in a gene-specific manner. These data allow new insights into the mechanisms that relate the electrophysiological consequences of mutations on specific genes to clinical manifestations and offer the possibility of complementing traditional therapy with gene-specific approaches.
Schwartz et al. (Tue,) studied this question.