What question did this study set out to answer?

To evaluate the pharmacokinetics of ribociclib across different ethnicities in breast cancer patients.

April 10, 2026Open Access

Comprehensive Ethnicity Assessment of Ribociclib Pharmacokinetics in Patients With Early and Advanced Breast Cancer

Key Points

To evaluate the pharmacokinetics of ribociclib across different ethnicities in breast cancer patients.
Conducted a pharmacokinetic analysis comparing Asian and non-Asian patients.
Reviewed dose recommendations for ribociclib in different ethnic groups.
Ribociclib pharmacokinetics were comparable between Asian and non-Asian patients.
Current dosing recommendations for Asian patients are supported by the findings.

Abstract

This comprehensive ethnicity assessment suggests comparable PK of ribociclib between Asian and non-Asian patients and supports current dose recommendations in Asian patients.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Cite this study

Ji et al. (Wed,) studied this question.

synapsesocial.com/papers/69d892d16c1944d70ce04007 — DOI: https://doi.org/10.1016/j.clinthera.2026.03.004

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Quantitative Assessment of Ribociclib Exposure–Response Relationship to Justify Dose Regimen in Patients with Advanced Breast Cancer· 2023 · 10 citations
Use of Pharmacokinetic and Pharmacodynamic Data to Develop the CDK4/6 Inhibitor Ribociclib for Patients with Advanced Breast Cancer· 2024 · 12 citations
Effect of food components on cytochrome P450 expression and activity· 2025 · 8 citations
The Role of Ethnicity in Variability in Response to Drugs: Focus on Clinical Pharmacology Studies· 2008 · 393 citations
Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer· 2016 · 2,003 citations

Authors

Yan Ji

F. Sun

M. Sato

Journals

Clinical Therapeutics

Actions

Institutions

Novartis (Switzerland)

National Taiwan University Hospital

Novartis (China)

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Comprehensive Ethnicity Assessment of Ribociclib Pharmacokinetics in Patients With Early and Advanced Breast Cancer

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Also consider