What question did this study set out to answer?

This research aims to explore how childhood trauma affects working memory through frontoparietal network flexibility in schizophrenia.

April 10, 2026Psychological Medicine0 citationsOpen Access

Dynamic frontoparietal flexibility and cognitive dysfunction in schizophrenia: disentangling the roles of symptom burden and childhood trauma

DHDanqing HuangCentral South University ZLZhening LiuCentral South University WTWenjian TanCentral South University

Key Points

This research aims to explore how childhood trauma affects working memory through frontoparietal network flexibility in schizophrenia.
Examined the relationship between childhood trauma and cognitive performance in schizophrenia
Assessed frontoparietal network flexibility using neuroimaging techniques
Analyzed symptom burden to understand its impact on cognition
Frontoparietal network flexibility mediates the effect of childhood trauma on working memory
Higher trauma exposure correlates with increased cognitive dysfunction
Symptom burden influences cognitive performance in patients with schizophrenia

Abstract

Our findings highlight the central role of FPN flexibility in mediating childhood trauma's effect on working memory in schizophrenia. This outlines a key pathway through which an early environmental risk (trauma) translates into cognitive and clinical manifestations in schizophrenia.

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Cite This Study

Huang et al. (Thu,) studied this question.

synapsesocial.com/papers/69d8946e6c1944d70ce05541 https://doi.org/https://doi.org/10.1017/s0033291726103869

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