Initiation and Continuation of Adalimumab with Methotrexate for Juvenile Idiopathic Arthritis-Associated Uveitis: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Key Points

• The study aims to evaluate the effectiveness of combining adalimumab with methotrexate for treating uveitis associated with juvenile idiopathic arthritis.
• Conducted a systematic review of randomized controlled trials.
• Analyzed data on the initiation and continuation of adalimumab therapy.
• Assessed relapse rates and steroid use in pediatric patients.
• Initiating adalimumab with methotrexate significantly lowers relapse risk.
• The therapy model supports steroid-sparing strategies.
• Vision preservation was confirmed in children with JIA-U.