Are IRX3 genetic defects associated with lethal cardiac arrhythmias such as idiopathic VF?
IRX3 genetic defects are identified as novel risk factors for idiopathic VF, offering potential for improved risk stratification for sudden cardiac death.
IRX3 genetic defects and resultant functional perturbation in the His-Purkinje system are novel genetic risk factors of idiopathic VF, and would improve risk stratification and preventive therapy for SCD in otherwise healthy hearts.
Koizumi et al. (Thu,) studied this question.