ZRANB1 depletion inhibits neuroblastoma progression by destabilizing MYCN through EZH2-mediated deubiquitination

Key Points

• The aim is to explore how ZRANB1 influences MYCN stability in neuroblastoma and its role as a therapeutic target.
• Identified ZRANB1 as a deubiquitinase.
• Examined the relationship between ZRANB1, EZH2, and MYCN.
• Analyzed MYCN stability in MYCN-amplified neuroblastoma cells.
• ZRANB1 depletion led to increased destabilization of MYCN.
• EZH2 is identified as a regulatory intermediary in this process.
• Establishing ZRANB1 as a therapeutic target shows potential for neuroblastoma treatment.

Abstract