Sequential nephron blockade vs . sequential renin–angiotensin system blockade on central and ambulatory blood pressure in resistant hypertension: A randomized clinical trial

Key Points

• The study aims to compare the effectiveness of sequential nephron blockade versus sequential renin–angiotensin system blockade on blood pressure.
• Randomized clinical trial design
• Patient population with resistant hypertension
• Comparison of sequential nephron blockade and renin–angiotensin system blockade
• Measurement of central and ambulatory blood pressure outcomes
• Sequential nephron blockade showed greater reduction in central systolic blood pressure and pulse pressure
• Renin–angiotensin system blockade was more effective at lowering heart rate
• Distinct hemodynamic responses suggest different treatment strategies for patients

Structured PICO

Abstract