What question did this study set out to answer?

The aim is to evaluate the impact of CD19-targeting CAR T cells on B-cell immunity in antisynthetase syndrome.

June 27, 2023Open Access

CD19-Targeting CAR T Cells for Myositis and Interstitial Lung Disease Associated With Antisynthetase Syndrome

Key Points

The aim is to evaluate the impact of CD19-targeting CAR T cells on B-cell immunity in antisynthetase syndrome.
Directed against B cells and plasmablasts
Combined with mycophenolate mofetil
Focus on inducing remission in refractory cases
Deeply reset B-cell immunity
Break pathologic B-cell and T-cell responses
Induce remission in refractory antisynthetase syndrome

Abstract

CD19-targeting CAR T cells directed against B cells and plasmablasts deeply reset B-cell immunity. Together with mycophenolate mofetil, CD19-targeting CAR T cells may break pathologic B-cell, as well as T-cell responses, inducing remission in refractory antisynthetase syndrome.

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Cite This Study

Pecher et al. (Tue,) studied this question.

synapsesocial.com/papers/69d8af9b183921ebcaae35bf https://doi.org/https://doi.org/10.1001/jama.2023.8753

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