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A surface-engineering approach to produce monodisperse nanoparticles functionalized for conjugations of various biomolecules is described. The oleic acid-capped nanoparticles are modified with triethoxysilylpropylsuccinic anhydride followed by reaction with aminated poly(ethylene glycol) (PEG) to render the nanoparticles hydrophilic and display amine groups at the free termini of PEG chains (see image). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Chen et al. (Mon,) studied this question.