Pregnant patients with Marfan's syndrome, particularly those with aortic diameters ≥40 mm, require careful counseling, individualized risk assessment, and potentially prophylactic aortic surgery prior to pregnancy.
Patients with MFS, especially those whose initial aortic diameters ≥40 mm, planning a pregnancy or currently pregnant should be carefully counseled about the maternal and fetal risks throughout pregnancy. MFS patients whose aortic diameters ≥40 mm should be advised to ideally await pregnancy until prophylactic aortic surgery. As MFS varies in its phenotypic expression, each patient's risk of adverse cardiac events should be assessed individually through a joint Maternal Fetal Medicine and Cardiology Center.
Kim et al. (Mon,) studied this question.