Does dexrazoxane reduce cardiotoxicity in patients with advanced breast cancer receiving doxorubicin-containing therapy?
Dexrazoxane is the first agent shown to significantly reduce doxorubicin-induced cardiotoxicity in patients with advanced breast cancer.
DZR had a significant cardioprotective effect as measured by noninvasive testing and clinical CHF. One of the two studies (088001) showed a lower response rate with DZR, but time to progression and survival were not significantly different. DZR is the first agent shown to reduce cardiotoxicity from doxorubicin.
Swain et al. (Tue,) studied this question.
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