March 11, 2010Open Access

Targeting Phosphoinositide-3-Kinase-δ with Theophylline Reverses Corticosteroid Insensitivity in Chronic Obstructive Pulmonary Disease

Key Points

Key points are not available for this paper at this time.

Abstract

Inhibition of oxidative stress dependent PI3K-δ activation by a selective inhibitor or theophylline provides a novel approach to reversing corticosteroid insensitivity in COPD.

Read Full Paperexternally

AI에게 질문

Bookmark

View Full Paper

Cite This Study

To et al. (Thu,) studied this question.

synapsesocial.com/papers/69da26c0ba6014a02e83636a https://doi.org/https://doi.org/10.1164/rccm.200906-0937oc

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Senescence Marker Protein-30 Protects Mice Lungs from Oxidative Stress, Aging, and Smoking2006 · 153 citations
2IGF-1 Protects Intestinal Epithelial Cells From Oxidative Stress-Induced Apoptosis2006 · 90 citations
3Implication of Phosphatidylinositol 3-Kinase Membrane Recruitment in Hydrogen Peroxide-Induced Activation of PI3K and Akt2003 · 91 citations
4A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression2002 · 513 citations
5Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: a randomised controlled trial1999 · 816 citations

AI에게 질문

Bookmark

View Full Paper