Does in-hospital stroke onset worsen clinical severity and mortality compared to out-of-hospital stroke onset in patients with acute brain infarction?
In-hospital onset ischemic stroke is associated with greater neurological severity and higher mortality at discharge compared to out-of-hospital onset.
Background and Purpose: The aim of the present study was to clarify the clinical characteristics of in-hospital onset stroke. Material and Methods: We analyzed 15,815 patients with acute brain infarction registered in the Japan Multicenter Stroke Investigators’ Collaboration (J-MUSIC) registry. Results: The in-hospital onset group included 694 (4.4%) patients and the out-of-hospital group included 15,121 (95.6%) patients. Atrial fibrillation (AF) was more common in the in-hospital onset group (34.6%) than in the out-of-hospital group (20.4%, p Conclusion: In-hospital stroke onset was not uncommon. The neurological deficits in patients with in-hospital onset stroke were severer and the outcome was worse than in those with out-of-hospital stroke. Therefore, a strategy to reduce in-hospital stroke onset should be implemented.
Kimura et al. (Sun,) studied this question.