Human semilunar valves undergo progressive, environmentally mediated adaptation from fetal to adult life, characterized by cellular quiescence and collagen maturation.
Fetal valves possess a dynamic/adaptive structure and contain cells with an activated/immature phenotype. During postnatal life, activated cells gradually become quiescent, whereas collagen matures, which suggests a progressive, environmentally mediated adaptation.
Aïkawa et al. (Mon,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: