Hemodynamic Disturbed Flow Induces Differential DNA Methylation of Endothelial Kruppel-Like Factor 4 Promoter In Vitro and In Vivo

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Abstract

Hemodynamics influence endothelial KLF4 expression through DNMT enrichment/myocyte enhancer factor-2 inhibition mechanisms of KLF4 promoter CpG methylation with regional consequences for atherosusceptibility.

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Jiang et al. (Wed,) studied this question.

synapsesocial.com/papers/69dad76c4e9a02dbaa684af0 https://doi.org/https://doi.org/10.1161/circresaha.115.303883

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