This manuscript proposes a biologically grounded, falsifiable hypothesis in which microtubule organization modulates neuronal excitability through classical biophysical pathways. The framework introduces coherence windows—transient intracellular regimes that stabilize ionic and dielectric conditions, shaping neuronal gain, integration timescales, and cross‑regional compatibility. The model is non‑quantum, non‑computational, and positions microtubules as modulatory infrastructure rather than information‑processing elements. Clear experimental predictions are provided to guide empirical testing across molecular, cellular, and systems neuroscience.
Robert Clark (Fri,) studied this question.