Parathyroid hormone assays in 2026: second versus third generation, standardization, and clinical interpretation

Key Points

• The aim is to investigate advancements in parathyroid hormone (PTH) assays and their implications for clinical interpretation.
• Reviewed recent developments in LC-MS/MS methods for PTH assays
• Analyzed approaches toward harmonization of assay standards
• Identified barriers including cost and technical complexity.
• Highlighted improvements in analytical comparability of PTH assays
• Emphasized the potential for better clinical interpretation of PTH levels
• Noted challenges that remain in standardization processes.