Integrated genomic and clinical indicators for predicting foetal chromosomal abnormalities: development and validation of a nomogram model

Key Points

• Develop a nomogram that integrates genomic and clinical indicators to predict foetal chromosomal abnormalities.
• Incorporated genomic technologies with clinical and ultrasound indicators.
• Developed a nomogram model for estimation of individual risk.
• Validated the model through clinical assessment.
• The nomogram provides precise risk assessments for foetal abnormalities.
• Supports clinicians in diagnostic decisions during pregnancies with suspected abnormalities.