Left ventricular segments failing to hypertrophy during pressure overload in 49% of subjects exhibited reduced fractional shortening (10.2% vs 24.9%) and lower ejection fraction (32.5% vs 49.8%).
Multiparametric MRI demonstrates that heterogeneous myocardial adaptation to pressure overload, specifically the failure of certain segments to hypertrophy, is linked to early regional and global ventricular dysfunction.
Absolute Event Rate: 0% vs 0%
Cardiac adaptation to chronic pressure overload is traditionally viewed as a uniform concentric hypertrophy; however, growing evidence suggests that the myocardium responds in a spatially heterogeneous manner. This study aimed to systematically map regional and temporal adaptation patterns of the left ventricle (LV) under experimental pressure overload using high-resolution multiparametric cardiac MRI, with the hypothesis that distinct regional adaptation phenotypes contribute to both local functional differences and global ventricular dysfunction. Thirty-seven male 129/SvEv mice underwent transverse aortic constriction (TAC) surgery and were followed longitudinally over 7 weeks. Cine imaging, T1- and T2-mapping were performed at baseline, 3 days, 4 weeks and 7 weeks using a 9.4 T small-animal scanner. A 200-sector LV segmentation enabled quantitative regional analysis of wall thickness, fractional shortening (FS) and relaxation times. Global and regional imaging parameters were correlated with histological and biochemical indices at study termination, and statistical analyses were performed using the Mann-Whitney test and correlation modelling, with p 2 = 0.58, p = 0.002), suggesting maladaptive regional remodeling. In conclusion, pressure overload elicits diverse regional adaptation, and failure to hypertrophy identifies myocardial territories prone to early dysfunction and global decline. Recognizing hypertrophy as an essential adaptive mechanism shifts the paradigm of pressure-overload remodeling. Multiparametric MRI provides a translational platform for detecting regional vulnerability and guiding early intervention.
Koch et al. (Thu,) reported a other. Left ventricular segments failing to hypertrophy during pressure overload in 49% of subjects exhibited reduced fractional shortening (10.2% vs 24.9%) and lower ejection fraction (32.5% vs 49.8%).