Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Key Points

• To investigate how advancing age influences the connection between cognitive impairment and brain volume in early multiple sclerosis.
• Conducted longitudinal MRI assessments to measure gray matter volume (GMV).
• Evaluated cognitive outcomes five years post first demyelinating event.
• Analyzed the impact of aging on the association between GMV and cognitive outcomes.
• Significant correlation found between GMV volumes and cognitive outcomes five years post-event.
• Advancing age correlated with changes in GMV and cognitive outcomes.
• Age modification suggests that older individuals may experience different cognitive impacts compared to younger ones.