Naphthalene derivatives from Diospyros wallichii

Three new naphthalene derivatives, 2-hydroxymethyl-1,5-dimethoxynaphthalen-4-ol (1), 2,2′-bis-hydroxymethyl-1,1′,5,5′-tetramethoxy-3,3′-binaphthalen-4,4′-diol (2), and 5,5′-dihydroxy-2,2′-dimethyl-7,7′-binaphthalen-1,1′,4,4′-tetraone (3), were isolated from the hexane and CH 2 Cl 2 extracts of the roots and fruits of Diospyros wallichii , along with sixteen known compounds comprising nine naphthoquinones (4–12), a coumarin (13), and six triterpenes (14–19). The structures of these compounds were established on the basis of spectroscopic data and comparison with reported values. The antibacterial, antifungal, and cytotoxic activities of naphthalene derivatives were also reported.