July 28, 2022Open Access

Transforming growth factor-β1 protects against LPC-induced cognitive deficit by attenuating pyroptosis of microglia via NF-κB/ERK1/2 pathways

YXYi XieChangchun University of Science and Technology XCXuejiao ChenHefei University of Technology YLYing LiThe People's Hospital of Guangxi Zhuang Autonomous Region

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Abstract

Our studies demonstrated TGF-β1 notably relieved the demyelinating injury and cognitive disorder in LPC-modeling mice, by attenuating the inflammatory pyroptosis of microglia via ERK1/2 and NF-κB pathways. Targeting TGF-β1 activity might serve as a promising therapeutic strategy in demyelinating diseases.

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Xie et al. (Thu,) studied this question.

synapsesocial.com/papers/69dbc4683d9adb00e7684f76 https://doi.org/https://doi.org/10.1186/s12974-022-02557-0

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