Coagulation and hematological variations in pregnancy: A cross-sectional study on hypertensive and normotensive females

Objective: To evaluate and compare coagulation and hematological parameters in hypertensive and normotensive pregnant women. Methods: This present cross-sectional study was carried out in the Departments of Pathology and Obstetrics mild preeclampsia ( n =39), and severe preeclampsia ( n =12). A significant progressive decrease in platelet count and significant increases in MPV, PDW, PT, aPTT, and D -dimer levels were associated with increasing severity of pregnancy-induced hypertension ( P <0.001). Women with severe preeclampsia had the lowest mean platelet counts and the highest coagulation parameter values compared to women with gestational hypertension, mild preeclampsia, and normotensive pregnancies. These findings indicate enhanced platelet activation, endothelial dysfunction, and activation of the coagulation-fibrinolytic system with worsening disease severity. Conclusions: Significant hematologic and coagulation abnormalities were present in women with pregnancy-induced hypertension. For better maternal-fetal outcomes and early management, routine monitoring is essential.