Treating Childhood Acute Lymphoblastic Leukemia without Cranial Irradiation
Key Points
The aim is to evaluate the safety of omitting prophylactic cranial irradiation in the treatment of childhood acute lymphoblastic leukemia (ALL).
Risk-adjusted chemotherapy was utilized in the treatment protocol.
ClinicalTrials.gov number NCT00137111 was referenced to indicate study registration.
Omission of prophylactic cranial irradiation did not negatively impact treatment outcomes.
Effective chemotherapy alone was sufficient to manage childhood ALL.
Abstract
With effective risk-adjusted chemotherapy, prophylactic cranial irradiation can be safely omitted from the treatment of childhood ALL. (ClinicalTrials.gov number, NCT00137111.)