Tumour necrosis factor α signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice

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Abstract

Enhancement of the TNF-alpha/TNFR mediated signalling pathway via activation of Kupffer cells in an autocrine or paracrine manner may be critically involved in the pathogenesis of liver fibrosis in this NASH animal model.

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Tomita et al. (Tue,) studied this question.

synapsesocial.com/papers/69dcae100de68e8319e53345 https://doi.org/https://doi.org/10.1136/gut.2005.071118

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