Intranasal Nanoemulsion-based In-Situ Gel Containing Dexlansoprazole: Formulation Development, In-Vitro and Ex-Vivo Evaluation

Key Points

• The aim is to develop a nanoemulsion-based gel formulation containing dexlansoprazole and evaluate its performance.
• Developed dex-lansoprazole-loaded nanoemulsion (DXL-NE)
• Conducted in vitro dissolution studies
• Planned ex vivo evaluations of the formulation
• DXL-NE showed improved in vitro dissolution compared to conventional forms
• Indicates potential enhancement in bioavailability
• Further in vivo studies needed to confirm findings