Key points are not available for this paper at this time.
Main observation and conclusion The 8+4 cycloaddition of indene‐2‐carbaldehydes with indole‐2,3‐quinodimethanes and pyrrolidone‐3,4‐dienes is described, affording indole and pyrrolidone annulated bicyclo4.2.1nonanes in a highly peri‐, diastereo‐, and enantioselective fashion in the presence of a secondary amine catalyst. This reaction, which proceeds through catalytically generated isobenzofulvenes, represents the first asymmetric version of high‐order 8+4 cycloaddition.
Zhao et al. (Fri,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: