December 20, 2001Open Access
Cyclooxygenase Inhibitors and the Antiplatelet Effects of Aspirin
Structured PICO
Does concomitant administration of ibuprofen, rofecoxib, acetaminophen, or diclofenac antagonize the irreversible platelet inhibition induced by aspirin?
P
Population
Patients with increased cardiovascular risk taking aspirin
I
Intervention
Concomitant administration of ibuprofen, rofecoxib, acetaminophen, or diclofenac
O
Outcome
Irreversible platelet inhibition induced by aspirinsurrogate
Concomitant use of ibuprofen may limit the cardioprotective effects of aspirin by antagonizing its antiplatelet activity.
Abstract
The concomitant administration of ibuprofen but not rofecoxib, acetaminophen, or diclofenac antagonizes the irreversible platelet inhibition induced by aspirin. Treatment with ibuprofen in patients with increased cardiovascular risk may limit the cardioprotective effects of aspirin.
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Authors
F
Francesca Catella-Lawson
American Red Cross
Muredach P. Reilly
Preventive Cardiology
S
Shiv Kapoor
M S Ramaiah University of Applied Sciences
Journals
New England Journal of Medicine
Actions
Institutions
University of Pennsylvania
References and Citations
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