Sarcomatoid urothelial carcinoma with constitutive PD-L1 overexpression

Key Points

• To assess the role of cPD-L1 expression in sarcomatoid urothelial carcinoma and its implications for treatment.
• Examined PD-L1 expression in sarcomatoid urothelial carcinoma cases.
• Analyzed signaling pathways involving IL6 and JAK-STAT3.
• Determined the influence of interferon α/γ on PD-L1 expression.
• cPD-L1 expression was identified in the majority of sarcomatoid urothelial carcinoma samples.
• IL6-JAK-STAT3 signaling was implicated in the regulation of cPD-L1 expression.
• Findings support the rationale for using immunotherapy in affected patients.