Genomic Insights Into Carbapenem‐Resistant Klebsiella pneumoniae in Pediatric Bloodstream Infections in Zhejiang, China (2019–2024)

Key Points

• The aim is to identify the mechanisms of carbapenem resistance in Klebsiella pneumoniae for effective management.
• Analyzed genomic data of Klebsiella pneumoniae isolates from pediatric bloodstream infections.
• Identified mechanisms of carbapenem resistance.
• Characterized dominant clones and their transmission patterns.
• Class B metalloenzymes are the primary mechanism of carbapenem resistance.
• The ST25-KL2 lineage is identified as the dominant clone.
• Increased risk of nosocomial transmission associated with the ST25-KL2 clone.