October 4, 2025Open Access

Metformin Blunts Vascular Insulin Sensitivity After Exercise Training in Adults at Risk for Metabolic Syndrome

SMSteven K. MalinRutgers, The State University of New Jersey EHEmily M. HeistonRutgers, The State University of New Jersey DBDaniel J. BattilloRutgers, The State University of New Jersey

Structured PICO

Does metformin blunt exercise training-mediated increases in vascular insulin sensitivity in adults at risk for metabolic syndrome?

Population

Adults at risk for metabolic syndrome

Intervention

Metformin combined with exercise training

Outcome

Vascular insulin sensitivity at the levels of conduit arteries and capillariessurrogate

Metformin blunts the beneficial effects of exercise training on vascular insulin sensitivity, inflammation, and glycemic control in adults at risk for metabolic syndrome.

Abstract

Met blunts exercise training-mediated increases in vascular insulin sensitivity at the levels of conduit arteries and capillaries, in parallel with altered inflammation and glycemic benefits.

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