Spatial clustering of recently activated cytotoxic lymphocytes improve association with overall survival in women with high grade serous ovarian cancer

Key Points

• The research aims to explore how the spatial distribution of recently activated cytotoxic lymphocytes impacts survival predictions in ovarian cancer.
• Validation of previous findings on CTL abundance and spatial contexture.
• Survival analyses performed using models incorporating spatial data.
• Focus on high grade serous ovarian cancer in women.
• Incorporating spatial contexture with CTL counts improved model fit.
• Positive association with overall survival observed when spatial data is included.