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NMD takes two PIN domains to tango. | Synapse

April 16, 20260 citationsOpen Access

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NMD takes two PIN domains to tango.

OMOliver Mühlemann EKEvangelos D. KarousisUniversity of Bern

Key Points

This research aims to explore the interaction of PIN domains in SMG5 and SMG6 and their role in mRNA decay.
Analysis of protein interactions between SMG5 and SMG6
Investigating the endonucleolytic activity of the composite catalytic site
Reviewing three separate studies for conclusive evidence.
PIN domains of SMG5 and SMG6 interact with each other.
The composite catalytic site shows physiological endonucleolytic activity.
Nonsense mRNA degradation is initiated by these interactions.

Abstract

Three new studies (Arpa et al. 2026; Kurscheidt et al. 2026; Modena et al. 2026) found that the PIN domains of SMG5 and SMG6, two proteins involved in nonsense-mediated mRNA decay (NMD), interact and show that the physiological endonucleolytic activity initiating the degradation of the nonsense mRNA is exerted by this composite catalytic site.

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Cite This Study

Mühlemann et al. (Wed,) studied this question.

synapsesocial.com/papers/69e07dc72f7e8953b7cbec0e https://doi.org/https://doi.org/10.48620/96866

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