MiR-4261 targeted YWHAE/CAST/GPX1 impairs the calcium regulatory function of PMCA4 in erythrocytes of myeloma

Key Points

• To investigate the role of MiR-4261 in regulating calcium function in erythrocytes of myeloma patients.
• Analyzed the targeting of MiR-4261 on 14-3-3ε, calpastatin, and GPX1.
• Examined the calcium regulatory function of PMCA4 in erythrocytes.
• Assessed impacts of MiR-4261 on erythrocyte calcium levels.
• MiR-4261 downregulates 14-3-3ε, calpastatin, and GPX1.
• Calcium overload in erythrocytes was observed.
• Peroxidative damage linked to impaired calcium regulation was noted.