Susceptibility‐Guided Versus Empirical First‐Line Therapy of Helicobacter pylori Infection in Adults: A Systematic Review and Meta‐Analysis

Key Points

• The research aims to compare the effectiveness of susceptibility-guided therapy versus empirical therapy for Helicobacter pylori infection in adults.
• Conducted a systematic review
• Performed a meta-analysis of therapy outcomes
• Analyzed eradication rates between susceptibility-guided and empirical regimens
• Susceptibility-guided therapy has non-inferior, often superior eradication rates compared to empirical regimens.
• The benefit of susceptibility testing is reduced where a bismuth quadruple therapy is already standard.