Is elevated systemic immune-inflammation index associated with cardiac resynchronization therapy nonresponse in patients with heart failure?
Elevated systemic immune-inflammation index may serve as a complementary biomarker for risk stratification to predict CRT nonresponse in heart failure patients.
Elevated SII was associated with an increased likelihood of CRT nonresponse and persistent inflammatory activity during follow-up. These findings suggest that SII reflects an unfavorable inflammatory and biological milieu related to impaired CRT response, rather than a direct causal mechanism. Systemic immune-inflammation index may serve as a complementary biomarker for risk stratification in patients undergoing CRT.
Şipal et al. (Wed,) studied this question.