What question did this study set out to answer?

To develop a metal-free method for the oxidative alkoxylation and amidation of benzofuran derivatives.

April 17, 2026

Room-Temperature Metal-Free Oxidative Alkoxylation/Amidation of Benzofuran-3(2H)-ones with Simple Alcohols and Nitriles

Key Points

To develop a metal-free method for the oxidative alkoxylation and amidation of benzofuran derivatives.
Employing simple alcohols and nitriles as reactants
Conducting reactions under mild temperature conditions
Focusing on synthesis of 2-monosubstituted benzofuran-3(2H)-ones
Synthesis achieved moderate to excellent yield of derivatives
Demonstration of broad substrate scope

Abstract

Metal-free oxidative alkoxylation/amidation of benzofuran-3(2H)-ones with alcohols and nitriles is disclosed, which enables the synthesis of a broad range of 2-monosubstituted benzofuran-3(2H)-ones in moderate to excellent yields under mild conditions....

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