Smooth Muscle Cell‐Derived Exosomal miR‐30a‐5p as a Novel Therapeutic Strategy for Erectile Dysfunction in Diabetes Mellitus

Key Points

• The research aims to explore the protective role of miR-30a-5p derived from smooth muscle cell exosomes in diabetic erectile dysfunction.
• Utilized exosomes from smooth muscle cells (NSMC-EXO)
• Investigated the targeting of Calm1 by miR-30a-5p
• Assessed the effects on pro-apoptotic and pro-fibrotic signaling pathways
• miR-30a-5p directly targets Calm1
• Significantly attenuates pro-apoptotic signaling
• Decreases pro-fibrotic signaling related to erectile dysfunction in diabetes